Mueller, Juergen L. and Schuierer, G. and Fischer-Barnicol, D. and Mobus, C. and Klein, H. E. (2001) Relevance of subcortical changes in tote-onset schizophrenia. A review and a fMRI study in a patient with bilateral globus pallidum necrosis. NERVENHEILKUNDE, 20 (4). pp. 210-216. ISSN 0722-1541
Full text not available from this repository.Abstract
Bilateral hypointense signal deviations with regard to the basal ganglia area might be induced by different reasons. In psychiatric diseases the pathological relevance of unspecific grey and white matter lesions in subcortical areas is still unclear especially in atypical courses, in late-onset schizophrenia cortical and subcortical abnormalities are more frequent on MRI. The clinical relevance of these findings however is controversial. We present a neuroimaging follow-up study including functional MRI in a patient with late-onset schizophrenia. Using different MRI sequences, a bilateral necrosis of the internal pallidum was found. To evaluate the functional relevance, a unilateral self-paced fingertapping study was performed under treatment with olanzapine and under haloperidol. We found a significant increase in BOLD-response in the contralateral primary sensorimotor area, the SMA and the putamen. Cerebellum and thalamus were significantly activated under olanzapine. With regard to cortical and subcortical activation we found no functional relevance of the pallidal necrosis compared to other psychotic inpatients under haloperidol and olanzapine. A literature review considering biological findings, symptoms, therapy and course of lore-onset schizophrenia is enclosed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARBON-MONOXIDE INTOXICATION; HALLERVORDEN-SPATZ DISEASE; LATE-LIFE SCHIZOPHRENIA; BASAL GANGLIA; NEUROLEPTIC-NAIVE; SENSORIMOTOR CORTEX; FINGER MOVEMENTS; MOTOR ACTIVATION; PUTAMEN NUCLEI; IRON CONTENT; fMRI; fingertapping study; neuroleptic therapy; olanzapine; haloperidol; basal ganglia; thalamus; late-onset schizophrenia; paraphrenia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2022 07:42 |
| Last Modified: | 14 Mar 2022 07:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41918 |
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