Poeck, Burkhard and Fischer, Susanne and Gunning, Dorian and Zipursky, S. Lawrence and Salecker, Iris (2001) Glial cells mediate target layer selection of retinal axons in the developing visual system of Drosophila. NEURON, 29 (1). pp. 99-113. ISSN 0896-6273
Full text not available from this repository. (Request a copy)Abstract
In the fly visual system, each class of photoreceptor neurons (R cells) projects to a different synaptic layer in the brain. R1-R6 axons terminate in the lamina, while R7 and R8 axons pass through the lamina and stop in the medulla. As R cell axons enter the lamina, they encounter both glial cells and neurons. The cellular requirement for R1-R6 targeting was determined using loss-of-function mutations affecting different cell types in the lamina. nonstop (encoding a ubiquitin-specific protease) is required for glial cell development and hedgehog for neuronal development. Removal of glial cells but not neurons disrupts R1-R6 targeting. We propose that glial cells provide the initial stop signal promoting growth cone termination in the lamina. These findings uncover a novel function for neuron-glial interactions in regulating target specificity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SH2/SH3 ADAPTER PROTEIN; OLFACTORY GLOMERULI; NERVOUS-SYSTEM; HOMEOBOX GENE; MELANOGASTER; NEURONS; CONNECTIONS; GUIDANCE; RECEPTOR; INSECT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2022 10:14 |
| Last Modified: | 07 Mar 2022 10:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41921 |
Actions (login required)
 |
View Item |
