Wendel, Hans P. and Philipp, Alois and Weber, Norbert and Birnbaum, Dietrich E. and Ziemer, Gerhard (2001) Oxygenator thrombosis: worst case after development of an abnormal pressure gradient - incidence and pathway. PERFUSION-UK, 16 (4). pp. 271-277. ISSN 0267-6591, 1477-111X
Full text not available from this repository. (Request a copy)Abstract
The development of an abnormally high pressure gradient (APG) before the membrane oxygenator (MO) is a complication that occurs during some extracorporeal circulation (ECC) procedures. The present study deals with the incidence of an APG and discusses a probable causative pathway by comparing surface-coated and uncoated oxygenation systems. Five thousand six hundred and seventeen adult ECCs were carried out (2581 without and 3036 with surface coatings). The incidence of an APG, therefore, amounted to 0.03% in the group with coated systems and 4.3% in the uncoated group. In addition, an in vitro study demonstrated significantly reduced adhesion and activation of platelets and leucocytes when the surfaces of the MOs were coated with heparin or polypeptides. The advantages of coating surfaces of ECC devices possibly depend on the selective adsorption of particular plasma proteins. These will presumably form a biocompatible membrane on the surface, and minimize pathological deposit of fibrin, platelets and other blood cells, and, therefore, implicate the prevention of an oxygenator failure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MOLECULAR-WEIGHT KININOGEN; CARDIOPULMONARY BYPASS; EXTRACORPOREAL-CIRCULATION; FIBRINOGEN RECEPTORS; ARTIFICIAL SURFACES; HEMOCOMPATIBILITY; ADHESION; FLOW; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Mar 2022 10:59 |
| Last Modified: | 07 Mar 2022 10:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41931 |
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