Juergensen, A. and Holzapfel, U. and Hein, R. and Stolz, W. and Buettner, R. and Bosserhoff, A. K. (2001) Comparison of two prognostic markers for malignant melanoma: MIA and S100 beta. TUMOR BIOLOGY, 22 (1). pp. 54-58. ISSN 1010-4283
Full text not available from this repository. (Request a copy)Abstract
It has recently been shown that the serum level of melanoma-inhibitory protein (MIA) provides useful information for the thera py and follow-up of patients with malignant melanoma, Previously, S100 beta has been described as a useful tumor marker for malignant melanoma. In this study, we compare the significance of the two markers in follow-up, therapy outcome and prognosis by measuring MIA and S100 beta serum levels in 50 melanoma patients, Serum levels were measured in patients with malignant melanomas of stages I-IV with at least 3 time points of measurement. Serial MIA and S100 beta measurements were obtained from 32 patients with stage IV disease in parallel to chemotherapy and from 18 patients with a history of stage I and stage II disease during follow-up. The response to chemotherapy in stage IV disease and relapse of melanoma during follow-up correlated with changes in MIA and S100 beta serum levels. In comparison, MIA revealed slightly higher specificity and sensitivity, In conclusion, both markers are useful for detection of progression from localized to metastatic disease during follow-up and for monitoring therapy of advanced melanomas. Copyright (C) 2000 S. Karger AG, Basel.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INHIBITORY ACTIVITY; METASTATIC MELANOMA; SERUM MARKER; PROTEIN; GENE; IDENTIFICATION; IMMUNOASSAY; CARTILAGE; CLONING; S-100; melanoma-inhibitory activity; S100 beta; tumor marker; malignant melanoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2022 07:20 |
| Last Modified: | 08 Mar 2022 07:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41953 |
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