Danser, A. H. Jan and Schunkert, Heribert (2000) Renin-angiotensin system gene polymorphisms: potential mechanisms for their association with cardiovascular diseases. EUROPEAN JOURNAL OF PHARMACOLOGY, 410 (2-3). pp. 303-316. ISSN 0014-2999, 1879-0712
Full text not available from this repository. (Request a copy)Abstract
Since the first description of the angiotensin-converting enzyme insertion/deletion polymorphism more than a decade ago, many hundreds of investigations have reported associations between this polymorphism and cardiovascular diseases. Subsequently, similar studies were performed in relationship with several other renin-angiotensin system gene polymorphisms, most notably the angiotensinogen M235T polymorphism and the angiotensin AT, receptor A1166C polymorphism. Surprisingly however, especially in view of the many contradictory results that have been obtained, very little attention has been paid to the mechanism(s) that may link these genetic variants and respective diseases. Here, we review the limited evidence that is currently available on the functional consequences (including compensatory mechanisms) of the above three renin-angiotensin system gene polymorphisms, in order to provide an explanation for the reported associations (or lack thereof) between these polymorphisms and cardiovascular diseases. (C) 2000 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONVERTING-ENZYME GENE; LEFT-VENTRICULAR HYPERTROPHY; TYPE-1 RECEPTOR GENE; INCREASED VASCULAR REACTIVITY; FAILING HUMAN HEARTS; ESSENTIAL-HYPERTENSION; BLOOD-PRESSURE; IN-VITRO; ANTIHYPERTENSIVE DRUGS; DELETION POLYMORPHISM; angiotensin; angiotensin-converting enzyme; angiotensinogen; angiotensin AT(1) receptor; polymorphism; renin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2022 10:37 |
| Last Modified: | 08 Mar 2022 10:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41969 |
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