Schlemmer, Richard and Spruss, Thilo and Bernhardt, Guenther and Schoenenberger, Helmut (2000) Does [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]-dichloroplatinum(II) act on the hormone-sensitive, murine breast cancer as a biological response modifier? Part II. Studies on the influence of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II) on the specific immune defense in MXT-M-3,2 breast cancer bearing mice. ARCHIV DER PHARMAZIE, 333 (12). pp. 397-403. ISSN 0365-6233
Full text not available from this repository. (Request a copy)Abstract
The anti-tumor activity of [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) on the MXT-M-3,2 breast cancer implanted into B6D2F(1) mice was not significantly reduced by splenectomy or co-administration of cyclosporine A. Neither did the use of T-lymphocyte-deficient NMRI (nu/nu) mice as hosts substantially influence its anti-tumor effect. Obviously, [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl) ethylenediamine]dichloroplatinum(II) does not act by an enhancement of the specific immune defense.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HOMOZYGOUS NUDE-MICE; NORMAL NMRI MICE; OVARIAN FOLLICLES; DIETHYLSTILBESTROL; THERAPY; OESTROGEN; STIMULANT; MECHANISM; COMPOUND; MOUSE; MXT-M-3,2 breast cancer; [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]dichloroplatinum(II); specific immune defense |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2022 17:10 |
| Last Modified: | 09 Mar 2022 17:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41985 |
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