Lucke, Andrea and Tessmar, Jörg and Schnell, Edith and Schmeer, Georg and Goepferich, Achim (2000) Biodegradable poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether diblock copolymers: structures and surface properties relevant to their use as biomaterials. BIOMATERIALS, 21 (23). pp. 2361-2370. ISSN 0142-9612
Full text not available from this repository. (Request a copy)Abstract
To obtain biodegradable polymers with variable surface properties for tissue culture applications, poly(ethylene glycol) blocks were attached to poly(lactic acid) blocks in a variety of combinations. The resulting poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether (Me.PEG-PLA) diblock copolymers were subject to comprehensive investigations concerning their bulk microstructure and surface properties to evaluate their suitability for drug delivery applications as well as for the manufacture of scaffolds in tissue engineering. Results obtained from H-1-NMR, gel permeation chromatography, wide angle X-ray diffraction and modulated differential scanning calorimetry revealed that the polymer bulk microstructure contains poly(ethylene glycol)-monomethyl ether (Me.PEG) domains segregated from poly(D,L-lactic acid) (PLA) domains varying with the composition of the diblock copolymers. Analysis of the surface of polymer films with atomic force microscopy and X-ray photoelectron spectroscopy indicated that there is a variable amount of Me.PEG chains present on the polymer surface, depending on the polymer composition. It could be shown that the presence of Me.PEG chains in the polymer surface had a suppressive effect on the adsorption of two model peptides (salmon calcitonin and human atrial natriuretic peptide). The possibility to modify polymer bulk microstructure as well as surface properties by variation of the copolymer composition is a prerequisite for their efficient use in the fields of drug delivery and tissue engineering. (C) 2000 Elsevier Science Ltd. AII rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PLA/PEO/PLA TRIBLOCK COPOLYMERS; HYDROLYTIC DEGRADATION; SALMON-CALCITONIN; BLOCK-COPOLYMERS; MICROSPHERES; PROTEIN; ADSORPTION; RELEASE; GLYCOL); block copolymer; biodegradable; poly(lactic acid); poly(ethylene glycol); surface properties; peptide adsorption |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Alumni or Retired Professors > Prof. Dr. Georg Schmeer |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2022 07:02 |
| Last Modified: | 14 Mar 2022 07:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41989 |
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