Hoffacker, Viola and Schultz, Anja and Tiesinga, James J. and Gold, Ralf and Schalke, Berthold and Nix, Wilfried and Kiefer, Reinhard and Mueller-Hermelink, Hans Konrad and Marx, Alexander (2000) Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. BLOOD, 96 (12). pp. 3872-3879. ISSN 0006-4971
Full text not available from this repository. (Request a copy)Abstract
Thymomas are the only tumors that are proven to generate mature T cells from immature precursors. It is unknown, however, whether intratumorous thymopoiesis has an impact on the peripheral T-cell pool and might thus be related to the high frequency of thymoma-associated myasthenia gravis, This study shows, using fluorescence-activated cell sortingbased analyses and T-cell proliferation assays, that thymopoiesis and T-cell function in thymomas correspond with immunologic alterations in the blood. Specifically, the proportion of circulating CD45RA(+)CD8(+) T cells is significantly increased in patients with thymoma compared with normal controls, in accordance with intratumorous T-cell development that is abnormally skewed toward the CD8(+) phenotype, Moreover, it is primarily the proportion of circulating CD45RA(+)CD8(+) T cells that decreases after thymectomy, The results also demonstrate that T cells reactive toward recombinant autoantigens are distributed equally between thymomas and blood, whereas T-cell responses to foreign antigen (ie, tetanus toroid) are seen only among circulating T cells and not among thymoma-derived T cells, These functional studies support the hypothesis that thymopoiesis occurring within thymomas alters the peripheral T-cell repertoire. Because many thymomas are enriched with autoantigen-specific T cells, a disturbance of circulating T-cell subset composition by export of intratumorous T cells may contribute to paraneoplastic autoimmune disease arising in patients with thymoma. (C) 2000 by The American Society of Hematology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | THYMIC EPITHELIAL TUMORS; MYASTHENIA-GRAVIS; ACETYLCHOLINE-RECEPTOR; GENE-EXPRESSION; LYMPHOCYTES-T; CD4(+); CLASSIFICATION; EMIGRANTS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2022 07:13 |
| Last Modified: | 14 Mar 2022 07:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/41990 |
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