Ackermann, G. and Abels, C. and Karrer, S. and Baeumler, W. and Landthaler, M. and Szeimies, Rolf-Markus (2000) Fluorescence-directed biopsy of basal cell carcinomas. HAUTARZT, 51 (12). pp. 920-924. ISSN 0017-8470
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Background and Objective. The diagnosis of precancerous and cancerous skin leasons in pretreated or scarred skin can be difficult. The determination of the right biopsy site in a suspected area depends largely on the physician's experience. Patients/Methods. The possibility of using a CCD-camera system and measuring tumor fluorescence following topical application of 5-aminolevulinic acid was employed in a single case to facilitate accurate choice of biopsy site. Results. An user-independent evaluation of the induced fluorescence intensity was achieved by means of the described optical system and digital imaging. The contrast of the acquired fluorescence images can be significantly enhanced and allows the determination of a threshold. As result an initial, clinically not visible basal cell carcinoma was detected and excised by a punch biopsy in toto. Conclusions. Using the described optical system the early recognition of a superficial basal cell carcinoma and the determination of the exact biopsy site was achieved in pretreated skin. The routine employment of the system will be assessed in a prospective study.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCED PROTOPORPHYRIN-IX; INDUCED PORPHYRIN FLUORESCENCE; 5-AMINOLEVULINIC ACID; PHOTODYNAMIC THERAPY; ENDOGENOUS PROTOPORPHYRIN; TUMORS; SELECTIVITY; DIAGNOSIS; DYSPLASIA; SURGERY; basal cell carcinoma; fluorescence; biopsy; 5-aminolaevulinic acid; digital imaging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2022 10:40 |
| Last Modified: | 14 Mar 2022 10:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42005 |
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