Grob, P. and Jilg, Wolfgang and Bornhak, H. and Gerken, G. and Gerlich, W. and Guenther, S. and Hess, G. and Huedig, H. and Kitchen, A. and Margolis, H. and Michel, G. and Trepo, C. and Will, H. and Zanetti, A. and Mushahwar, I. (2000) Serological pattern "anti-HBc alone": Report on a workshop. JOURNAL OF MEDICAL VIROLOGY, 62 (4). pp. 450-455. ISSN 0146-6615
Full text not available from this repository.Abstract
In areas with low hepatitis B virus (HBV) endemicity such as most parts of Europe and the United States "anti-HBc alone" is found in 10-20% of all individuals with HBV markers, i.e., 1-4% of the population. In about 10% of these individuals HBV DNA is detected by PCR, the proportions varying greatly depending on the population studied, being highest in individuals coinfected with hepatitis C virus (HCV) (above 35%) and HIV (above 85%). A small proportion of individuals with "anti-HBc alone" are in the window phase of an HBV infection or in a stage of late HBV immunity. For the large proportion of these individuals this is not the case and they are thought to have an unresolved HBV-infection or a chronic infection in a late or "low grade" productive state. Currently, limited studies have been performed concerning the clinical aspects of individuals with "anti-HBc alone" and suspected chronic HBV infection. The majority of these individuals seem to be healthy. Some chronic carriers with "anti-HBc alone," however, do present signs of chronic hepatitis. individuals with "anti-HBc alone" are potentially infectious. This is exemplified by a few case reports of HBV transmission to sexual contacts, perinatal transmission between mother and newborns and in blood recipients. Recommendations are given in relation to both the diagnostic and therapeutic procedures in the individuals with "anti-HBc alone" and in the blood banking and transplantation services. J. Med. Virol 62:450-455, 2000. (C) 2000 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEPATITIS-B VIRUS; ACUTE VIRAL-HEPATITIS; SURFACE-ANTIGEN; C VIRUS; CORE ANTIGEN; BLOOD-DONORS; ENVELOPE PROTEIN; INFECTION; HBSAG; MUTANT; HBV markers; HBV serology; anti-HBc; "anti-HBc alone" |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2022 14:36 |
| Last Modified: | 14 Mar 2022 14:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42014 |
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