Neff, S. and Abels, C. and Szeimies, Rolf-Markus (2000) Photodynamic therapy in dermatology. MEDIZINISCHE WELT, 51 (12). pp. 410-414. ISSN 0025-8512
Full text not available from this repository. (Request a copy)Abstract
Photodynamic therapy is based on the simultaneous interaction of a photosensitizer (mainly porphyrins), light and oxygen and leads to a photooxidative reaction inside the targeted tell. Depending on the dose (photosensitizer or light) and on the subcellular distribution of the sensitizer a cytotoxic or an immunomodulatory effect results. The reactive oxygen species mainly responsible for these effects is singlet oxygen. In Dermatology, superficial, non-pigmented tumors (tumor thickness <3 mm) e.g. basal cell carcinomas, or initial squamous cell carcinomas, or their precursors like Bowen's disease or salar keratoses, are the main indications. The topical application of 5-aminolevulinic acid (ALA), a heme precursor, which induces the formation of the photosensitizing porphyrin in vive, does not cause a long lasting cutaneous photosensitivity as observed using Photofrin(R), the only approved photosensitizer so for. Using ALA-PDT, the cure rates are comparable to those of standard therapeutic regimens, but of advantage ore the cosmetic results and the lack of invasiveness of this method. In addition, inflammatory dermatoses, like psoriasis vulgaris or virus induced skin diseases, may be treated efficiently by POT. At present, clinical phase-ill-studies ore conducted to prove the efficacy of the above mentioned indications. Photodynamic therapy in dermatology.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMATOPORPHYRIN DERIVATIVE PHOTORADIATION; 5-AMINOLEVULINIC ACID; SINGLET OXYGEN; TUMOR; CELLS; RELEASE; PHOTOTOXICITY; TISSUE; DAMAGE; INVIVO; photodynamic therapy; photofrin; 5-aminolevulinic acid; skin tumors; porphyrins |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Mar 2022 06:46 |
| Last Modified: | 15 Mar 2022 06:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42021 |
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