Kaminski, Wolfgang E. and Piehler, Armin and Schmitz, Gerd (2000) Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: Tandem linkage with the minor histocompatibility antigen HA-1 gene. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 278 (3). pp. 782-789. ISSN 0006-291X
Full text not available from this repository. (Request a copy)Abstract
We have recently cloned a novel cholesterol-responsive ABC transporter, designated ABCA7, which is predominantly expressed in human leukocytes. Here we report the structure of the human ABCA7 gene. The ABCA7 gene spans a region of similar to 32 kb and comprises 46 exons. Its putative promoter sequence contains potential binding sites for transcription factors with roles in hematopoiesis and cholesterol metabolism. Surprisingly, sequence analysis of the ABCA7 3' gene flanking region revealed that the terminal exon of ABCA7 borders immediately on the 5' end of the coding region of the recently identified human minor histocompatibility antigen HA-1. We demonstrate that the coding regions of ABCA7 and HA-1 are physically separated by a 1.7-kb intergene region. Subsequent genomic structure analysis showed that the HA-1 gene consists of 23 exons which extend across a 16-kb genomic region. Our results provide evidence that the genes for the human minor histocompatibility antigen HA-1 and the ABC transporter ABCA7 are arranged in a head-to-tail array and that both genes localize to a common locus of similar to 48 kb size on chromosome 19p13.3. (C) 2000 Academic Press.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BINDING CASSETTE TRANSPORTER-1; VERSUS-HOST DISEASE; TANGIER-DISEASE; MARROW TRANSPLANTATION; PROTEINS; PROMOTER; DONORS; IDENTIFICATION; EXPRESSION; INVENTORY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Mar 2022 08:16 |
| Last Modified: | 15 Mar 2022 08:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42042 |
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