Keyl, Cornelius and Schneider, Annette and Dambacher, Martin and Wegenhorst, Ulrike and Ingenlath, Matthias and Gruber, Michael and Bernardi, Luciano (2000) Dynamic cardiocirculatory control during propofol anesthesia in mechanically ventilated patients. ANESTHESIA AND ANALGESIA, 91 (5). pp. 1188-1195. ISSN 0003-2999
Full text not available from this repository. (Request a copy)Abstract
We evaluated dynamic cardiovascular control by spectral analytical methods in 20 young adults anesthetized with propofol (2.5 mg/kg, followed by continuous infusion of 0.1 mg/kg/min) and in an awake control group during cyclic stimulation of the carotid baroreceptors via sinusoidal neck suction at 0.2 Hz (baroreflex response mediated mainly by vagal activity) and at 0.1 Hz (baroreflex response mediated by vagal and sympathetic activity). During anesthesia and mechanical ventilation at 0.25 Hz, major underdampened hemodynamic oscillations occurred at 0.055 +/- 0.012 Hz. The response of RR intervals to baroreceptor stimulation at 0.2 Hz was markedly decreased during anesthesia (median of transfer function magnitude between neck suction and RR intervals 3% of the awake control). Blood pressure response to baroreceptor stimulation at 0.1 Hz was significantly decreased during anesthesia to 26% (systolic blood pressure), and 44% (diastolic blood pressure) of the awake control. There was a significant delay in baroreflex effector responses during anesthesia. Our results demonstrate a markedly depressed vagally mediated heart rate response and an impaired blood pressure response to cyclic baroreceptor stimulation during propofol anesthesia in mechanically ventilated patients. The disturbed baroreflex control is accompanied by an irregular dynamic behavior of cardiovascular regulation, indicating a decreased stability of the control system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESPIRATORY SINUS ARRHYTHMIA; HEART-RATE-VARIABILITY; ARTERIAL-PRESSURE; BARORECEPTOR REFLEX; SPECTRAL-ANALYSIS; BLOOD-PRESSURE; NERVE ACTIVITY; RR-INTERVAL; HUMANS; RESPONSES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Mar 2022 14:10 |
| Last Modified: | 15 Mar 2022 14:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42068 |
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