Hantschel, Markus and Pfister, Karin and Jordan, Andreas and Scholz, Regina and Andreesen, Reinhard and Schmitz, Gerd and Schmetzer, Helga and Hiddemann, Wolfgang and Multhoff, Gabriele (2000) Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. CELL STRESS & CHAPERONES, 5 (5). pp. 438-442. ISSN 1355-8145
Full text not available from this repository. (Request a copy)Abstract
A tumor-selective cell surface localization of heat shock protein 70 (Hsp70), the major heat-inducible member of the Hsp70 group, correlates with an increased sensitivity to lysis mediated by human natural killer (NK) cells and, therefore, might be of clinical relevance. With the exception of mammary carcinomas, an Hsp70 plasma membrane expression was found on freshly isolated human biopsy material of colorectal, lung, neuronal, and pancreas carcinomas, liver metastases, and leukemic blasts of patients with acute myelogenous leukemia. Since normal tissues and bone marrow of healthy human individuals do not express Hsp70 on the cell surface, Hsp70 can be considered as a tumor-selective structure in vivo. Furthermore, we demonstrate that autologous, Hsp70-positive leukemic blasts can be killed by NK cells stimulated with low doses of interleukin 2 plus recombinant Hsp70 protein.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEAT-SHOCK-PROTEIN; NATURAL-KILLER-CELLS; CYTOTOXIC T-LYMPHOCYTES; IMMUNITY; SURFACE; CANCER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Mar 2022 15:58 |
| Last Modified: | 16 Mar 2022 15:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42072 |
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