Mallow, H. and Trindl, A. and Loeffler, Georg (2000) Production of angiotensin II receptors type one (AT1) and type two (AT2) during the differentiation of 3T3-L1 preadipocytes. HORMONE AND METABOLIC RESEARCH, 32 (11-12). pp. 500-503. ISSN 0018-5043
Full text not available from this repository. (Request a copy)Abstract
During their development from progenitor cells, adipocytes not only express enzymatic activities necessary for the storage of triglycerides, but also achieve the capability to produce a number of endocrine factors such as leptin, tumor necrosis factor alpha (TNF alpha), complement factors, adiponectin/adipoQ, plasminogen activator inhibitor-1 (PAI-1), angiotensin II and others. Angiotensin II is produced from angiotensinogen by the proteolytic action of renin and angiotensin-converting enzyme; and several data point to the existence of a complete local renin-angiotensin system in adipose tissue, including angiotensin II receptors. In this study, we directly monitored the production of angiotensin II type one receptor (AT1) and angiotensin II type two receptor (AT2) proteins during the adipose conversion of murine 3T3-L1 preadipocytes by immunodetection with specific antibodies. AT1 receptors could be detected throughout the whole differentiation period, The strong AT2 signal in preadipocytes however was completely lost during the course of differentiation, which suggests that expression of AT2 receptors is inversely correlated to the adipose conversion program.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN ADIPOSE-TISSUE; GLYCEROPHOSPHATE DEHYDROGENASE; CELLS; CONVERSION; RAT; SYSTEM; RENIN; EXPRESSION; ADIPOCYTES; ENZYMES; renin-angiotensin system; metabolic syndrome; adiposity; adipocyte development |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Mar 2022 06:37 |
| Last Modified: | 21 Mar 2022 06:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42088 |
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