Gruss, Claus and Zillikens, Detlef and Hashimoto, Takashi and Amagai, Masayuki and Kroiss, Maximilian and Vogt, Thomas and Landthaler, Michael and Stolz, Wilhelm (2000) Rapid response of IgA pemphigus of subcorneal pustular dermatosis type to treatment with isotretinoin. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 43 (5). pp. 923-926. ISSN 0190-9622
Full text not available from this repository. (Request a copy)Abstract
Diagnosing IgA pemphigus and distinguishing between its 2 subtypes, intraepidermal neutrophilic IgA dermatosis type and subcorneal pustular dermatosis type, is important because treatment of IgA pemphigus has to be different from treatment of other blistering autoimmune dermatoses. We present a patient with subcorneal pustular dermatosis type of IgA pemphigus who rapidly responded to systemic treatment with isotretinoin. Specific diagnosis was established by detecting IgA serum activity to desmocollin 1 by indirect immunofluorescence microscopy on unfixed COS7 cells transfected with desmocollin 1. No IgA or IgG serum reactivity was found to recombinant forms of desmogleins 1 and 3 by an antigen-specific enzyme-linked immunosorbent assay The disease was not effectively controlled by conventional therapeutic regimens. Systemic treatment with isotretinoin 20 mg daily led to complete clearance of skin lesions within 3 weeks. Assaying IgA serum reactivity to desmocollin 1, desmoglein 1, and desmoglein 3 as a valuable method for establishing the diagnosis and differentiating the 2 subtypes of IgA pemghigus. Isotretinoin was an effective drug in the treatment of subcorneal pustular dermatosis type of IgA pemphigus in this patient.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VESICULOPUSTULAR DERMATOSIS; AUTOANTIBODIES; LOCALIZATION; FOLIACEUS; ANTIGEN; AUTOANTIGENS; ANTIBODIES; MONOCYTE; SKIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 21 Mar 2022 07:42 |
| Last Modified: | 21 Mar 2022 07:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42104 |
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