Schmitz, Gerd and Kaminski, Wolfgang E. and Orso, Evelyn (2000) ABC transporters in cellular lipid trafficking. CURRENT OPINION IN LIPIDOLOGY, 11 (5). pp. 493-501. ISSN 0957-9672
Full text not available from this repository.Abstract
ATP-binding cassette (ABC) transporters constitute a group of evolutionary highly conserved cellular transmembrane transport proteins. Recent work has implicated ABC transporters in cellular transmembrane lipid transport and hereditary diseases have been causatively linked to defective ABC transporters translocating lipid compounds. The emerging concept that a defined subset of ABC transporters is intimately involved in cellular lipid trafficking has recently been substantiated convincingly by the finding that ABCA1 plays a central role in the regulation of HDL metabolism and macrophage targeting to the RES or the vascular wall. Differentiation dependent expression of a large number of ABC transporters in monocytes/macrophages and their regulation by sterol flux render these transporter molecules potentially critical players in atherogenesis and other chronic inflammatory diseases, Curr Opin Lipidol 11:493-501. (C) 2000 Lippincott Williams & Wilkins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BINDING CASSETTE TRANSPORTER-1; DISEASE GENE ABCR; TRANSMEMBRANE CONDUCTANCE REGULATOR; FAMILIAL INTRAHEPATIC CHOLESTASIS; DUBIN-JOHNSON-SYNDROME; MAP KINASE CASCADE; TANGIER-DISEASE; P-GLYCOPROTEIN; STARGARDT-DISEASE; PLASMA-MEMBRANE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 06 May 2021 05:20 |
| Last Modified: | 06 May 2021 05:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42155 |
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