Torzewski, Michael and Rist, Carsten and Mortensen, Richard F. and Zwaka, Thomas P. and Bienek, Magda and Waltenberger, Johannes and Koenig, Wolfgang and Schmitz, Gerd and Hombach, Vinzenz and Torzewski, Jan (2000) C-reactive protein in the arterial intima - Role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 20 (9). pp. 2094-2099. ISSN 1079-5642
Full text not available from this repository.Abstract
Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A specific CRP receptor is demonstrated on monocytes in vitro as well as in vivo,and blockage of the receptor by use of a monoclonal anti-receptor antibody completely abolishes CRP-induced chemotaxis. CRP may play a major role in the recruitment monocytes during atherogenesis. (Arterioscler Thromb Vasc Biol. 2000;20:2094-2099.).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AMERICAN-HEART-ASSOCIATION; ATHEROSCLEROTIC LESIONS; IMMUNOHISTOCHEMICAL LOCALIZATION; CHEMOATTRACTANT PROTEIN-1; CARDIOVASCULAR-DISEASE; COMPLEMENT ACTIVATION; NEUTROPHIL CHEMOTAXIS; VASCULAR-LESIONS; UNSTABLE ANGINA; CELLS; C-reactive proteins; C-reactive protein receptors; monocytes; chemotaxis; atherogenesis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2022 15:22 |
| Last Modified: | 23 Mar 2022 15:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42217 |
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