Straub, Rainer H. and Miller, Luitpold E. and Schoelmerich, Juergen and Zietz, Bettina (2000) Cytokines and hormones as possible links between endocrinosenescence and immunosenescence. JOURNAL OF NEUROIMMUNOLOGY, 109 (1). pp. 10-15. ISSN 0165-5728
Full text not available from this repository. (Request a copy)Abstract
Deterioration of the immune system and the endocrine system during aging is thought to contribute to increased morbidity and mortality. Since bidirectional interrelations of both systems are present in the young and in the elderly, endocrinosenescence modulates the immune system and immunosenescence changes the endocrine system. This review focuses on age-related changes of the two systems and provides examples for the interaction of both systems during aging. It is demonstrated that both systems modulate each other in a probably unfavorable way which may be a cofactor in the aging process. Understanding of these bidirectional physiological mechanisms will help to define targets for therapeutical intervention to improve the health of aging people. (C) 2000 Elsevier Science BN. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; BLOOD MONONUCLEAR-CELLS; FETAL ADRENAL-CELLS; IMMUNE-SYSTEM; IN-VITRO; INTERLEUKIN-6; AGE; DEHYDROEPIANDROSTERONE; SECRETION; IL-6; cytokines; hormones; endocrinosenescence; immunosenescence; aging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Mar 2022 14:13 |
| Last Modified: | 28 Mar 2022 14:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42247 |
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