Steidler, Lothar and Hans, Wolfgang and Schotte, Lieven and Neirynck, Sabine and Obermeier, Florian and Falk, Werner and Fiers, Walter and Remaut, Erik (2000) Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. SCIENCE, 289 (5483). pp. 1352-1355. ISSN 0036-8075
Full text not available from this repository.Abstract
The cytokine interleukin-10 (IL-10) has shown promise in clinical trials for treatment of inflammatory bower disease (IBD), Using two mouse models, we show that the therapeutic dose of IL-10 can be reduced by Localized delivery of a bacterium genetically engineered to secrete the cytokine, Intragastric administration of IL-10-secreting Lactococcus lactis caused a 50% reduction in colitis in mice treated with dextran sulfate sodium and prevented the onset of colitis in IL-10(-/-) mice. This approach may Lead to better methods for cost-effective and Long-term management of IBD in humans.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MONOCLONAL-ANTIBODY CA2; CROHNS-DISEASE; PREVENTS COLITIS; MICE; INFLAMMATION; ENTEROCOLITIS; RESPONSES; INDUCTION; CYTOKINE; INTEGRIN; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2022 05:15 |
| Last Modified: | 29 Mar 2022 05:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42264 |
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