Kallinowski, Birgit and Knoell, A. and Lindner, E. and Saenger, R. and Stremmel, W. and Vollmar, J. and Zieger, B. and Jilg, Wolfgang (2000) Can monovalent hepatitis A and B vaccines be replaced by a combined hepatitis A/B vaccine during the primary immunization course? VACCINE, 19 (1). pp. 16-22. ISSN 0264-410X
Full text not available from this repository. (Request a copy)Abstract
A combined hepatitis A/B vaccine (Twinrix Adult(TM)) has been licensed in Germany since 1997. We investigated possible differences in immunogenicity and safety when changing over from vaccinations with monovalent vaccines made by different manufacturers to vaccinations with the combined hepatitis A/B vaccine in an open, randomized, multicenter trial. We therefore compared four different schemes changing over from concomitant vaccinations with monovalent vaccines against hepatitis A and B (Havrix 1440(TM) + Engerix-B(TM) or Vaqta(TM) + Gen H-B-Vax(TM)) to combined vaccination against hepatitis A + B with three injections of the combined hepatitis A/B vaccine (0, 1, and 6 month schedule). Local and general symptoms were mostly mild in all five groups. With complete three-dose course using the combined vaccine or an early changeover from monovalent vaccines to the combined vaccine, higher overall anti-HBs seroprotection rates and geometric mean concentrations (GMCs) against hepatitis B could be achieved as early as after 2 months as compared to those groups switching later to the combined vaccine. This study demonstrated for the first time that switching from monovalent hepatitis A and B vaccinations to the combined hepatitis A and B vaccination has no negative influence on the tolerability and improves the immunogenicity. (C) 2000 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURFACE-ANTIGEN; ANTIBODY; IMMUNOGENICITY; REACTOGENICITY; ADULTS; immunogenicity; reactogenicity; hepatitis A/B vaccination; monovalent vaccines; combination vaccine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2022 05:34 |
| Last Modified: | 29 Mar 2022 05:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42268 |
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