Hubacek, J. A. and Stueber, F. and Froehlich, D. and Book, M. and Wetegrove, S. and Rothe, G. and Schmitz, Gerd (2000) The common functional C(-159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality. GENES AND IMMUNITY, 1 (6). pp. 405-407. ISSN 1466-4879
Full text not available from this repository. (Request a copy)Abstract
Sepsis is characterised by a systemic inflammatory response to bacterial products during infection, which interestingly both in humans and animal models is gender associated with a higher susceptibility of males than females. The CD14 receptor is involved in activation of cells by lipopolysaccharides released from Gram-negative bacteria and, as recently shown, also by products of Gram-positive bacteria (eg, peptidoglycans and lipoleichoic acid). The functional relevance of a C(-159)T CD14 polymorphism recently has been shown based on correlation of the T allele to higher plasma levels of soluble CD14, and higher membrane expression on monocytes. We, therefore, now analysed this CD14 polymorphism in 204 patients with severe sepsis and 247 controls. No significant difference of allele frequencies was observed between sepsis patients and controls neither for males nor females. Mortality also was not associated with the polymorphism studied. This may suggest that other mechanisms for lipopolysaccharide recognition, such as the recently described Toll-like receptors are important for inflammatory cell activation in sepsis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIRCULATING SOLUBLE CD14; GRAM-POSITIVE SEPSIS; MYOCARDIAL-INFARCTION; HUMAN MONOCYTES; ORGAN FAILURE; LPS-BINDING; GENE; MICE; EXPRESSION; RELEASE; sepsis; CD14; polymorphism; infection; lipopolysaccharide |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2022 09:39 |
| Last Modified: | 29 Mar 2022 09:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42296 |
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