Aiglstorfer, Iris and Hendrich, Ingo and Moser, Christiane and Bernhardt, Günther and Dove, Stefan and Buschauer, Armin (2000) Structure-activity relationships of neuropeptide YY1 receptor antagonists related to BIBP 3226. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 10 (14). pp. 1597-1600. ISSN 0960-894X
Full text not available from this repository. (Request a copy)Abstract
Analogues of BIBP 3226, (R)-N-alpha-diphenylacetyl-N-(4-hydroxybenzyl)argininamide, were synthesized and investigated for Y-1 antagonism (Ca2+-assay, HEL cells) and binding on Y-1, Y-2 and Y-5 receptors. Replacing the benzylamino by a tetrahydrobenzazepinyl group preserves most of the Y-1 activity. Combination with a N-G-phenylpropyl arginine and a N-alpha-p-biphenyly-lacetyl moiety shifted the NPY receptor selectivity towards Y-5 (C) 2000 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2022 12:36 |
| Last Modified: | 30 Mar 2022 12:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42315 |
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