Kaminski, Wolfgang E. and Orso, Evelyn and Diederich, Wendy and Klucken, Jochen and Drobnik, Wolfgang and Schmitz, Gerd (2000) Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 273 (2). pp. 532-538. ISSN 0006-291X
Full text not available from this repository. (Request a copy)Abstract
We report the identification of the full-length cDNA for a novel ATP-binding cassette (ABC) transporter from human macrophages. The mRNA is of 6.8 kb size and contains an open reading frame encoding a polypeptide of 2146 amino acids with a calculated molecular weight of 220 kDa. The predicted protein product is composed of two transmembrane domains and two nucleotide binding folds indicating that it pertains to the group of full-size ABC transporters. The novel transporter shows highest protein sequence homology with the recently cloned human cholesterol and phospholipid exporter ABCA1 (54%) and the human retinal transporter ABCR (49%), both members of the ABC transporter subfamily A. In accordance with the currently proposed classification, the novel transporter was designated ABCA7. ABCA7 mRNA was detected predominantly in myelo-lymphatic tissues with highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. Expression of ABCA7 is induced during in vitro differentiation of human monocytes into macrophages. In macrophages, both the ABCA7 mRNA and protein expression are upregulated in the presence of modified low density lipoprotein and downregulated by HDL,. Our results suggest a role for ABCA7 in macrophage transmembrane lipid transport. (C) 2000 Academic Press.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE GENE ABCR; TANGIER-DISEASE; MUTATIONS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Mar 2022 13:10 |
| Last Modified: | 30 Mar 2022 13:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42329 |
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