Schweda, Frank and Riegger, Guenter A. J. and Kurtz, Armin and Kraemer, Bernhard K. (2000) Store-operated calcium influx inhibits renin secretion. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 279 (1). F170-F176. ISSN 1931-857X, 1522-1466
Full text not available from this repository. (Request a copy)Abstract
On the basis of evidence that changes in the extracellular concentration of calcium effectively modulate renin secretion from renal juxtaglomerular cells, our study aimed to determine the effect of calcium influx activated by depletion of intracellular calcium stores on renin secretion. For this purpose we characterized the effects of the endoplasmatic Ca2+-ATPase inhibitors thapsigargin (300 nM) and cyclopiazonic acid (20 mu M) on renin secretion from isolated perfused rat kidneys. We found that Ca2+-ATPase inhibition caused a potent inhibition of basal renin secretion as well as renin secretion activated by isoproterenol, bumetanide, and by a fall in the renal perfusion pressure. The inhibitory effect of Ca2+-ATPase inhibition on renin secretion was reversed within seconds by lowering of the extracellular calcium concentration into the submicromolar range but was not affected by lanthanum, gadolinium, flufenamic acid, or amlodipine. These data suggest that calcium influx triggered by release of calcium from internal stores is a powerful mechanism to inhibit renin secretion from juxtaglomerular cells. The store-triggered calcium influx pathway in juxtaglomerular cells is apparently not sensitive to classic blockers of the capacitative calcium entry pathway.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTRACELLULAR CA2+ STORES; PERFUSED RAT KIDNEYS; PAROTID ACINAR-CELLS; JUXTAGLOMERULAR CELLS; CYTOSOLIC CALCIUM; CHANNEL AGONIST; ANGIOTENSIN-II; TUMOR PROMOTER; MAST-CELLS; BAY K-8644; thapsigargin; cyclopiazonic acid; endoplasmatic calcium-adenosinetriphosphatase; isolated perfused rat kidney |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Frank Schweda |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Apr 2022 05:39 |
| Last Modified: | 05 Apr 2022 05:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42332 |
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