Langstein, Joachim and Becke, Florian M. and Soellner, Liane and Krause, Gitte and Brockhoff, Gero and Kreutz, Marina and Andreesen, Reinhard and Schwarz, Herbert (2000) Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 273 (1). pp. 117-122. ISSN 0006-291X
Full text not available from this repository.Abstract
CD137 (ILA/4-1BB), a member of the TNF receptor family, regulates activation, survival and proliferation of primary human monocytes, Here we compare the activities of lipopolysaccharide (LPS), a classical and potent monocyte activator to that of CD137. LPS is a more potent activator of monocytes, as evidenced by a stronger induction of the proinflammatory cytokine IL-8, However, CD137 could further increase maximal cytokine induction by LPS, which points to separate signaling pathways for LPS and CD137. Also, expression of myc was only induced by the combination of CD137 and LPS. Expression of macrophage colony-stimulating factor is induced more potently by CD137, but an additive effect is obtained by the combination of CD137 and LPS. Monocyte/macrophage survival and proliferation is only induced by CD137. LPS counteracts both activities of CD137 via activation induced cell death. While LPS has a role in activation of monocytes in innate immunity, the CD137 receptor/ligand system seems to deliver an activating signal to monocyte in acquired immunity. (C) 2000 Academic Press.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-RECEPTOR FAMILY; CD28 COSTIMULATION; APOPTOSIS; GROWTH; 4-1BB; MEMBER; DIFFERENTIATION; MACROPHAGES; EXPRESSION; DEATH; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Apr 2022 12:47 |
| Last Modified: | 05 Apr 2022 12:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42397 |
Actions (login required)
 |
View Item |
