Hildebrandt, Gerhard and Holler, Ernst and Woenkhaus, M. and Quarch, G. and Reichle, A. and Schalke, B. and Andreesen, Reinhard (2000) Acute deterioration of Charcot-Marie-Tooth disease IA (CMT IA) following 2 mg of vincristine chemotherapy. ANNALS OF ONCOLOGY, 11 (6). pp. 743-747. ISSN 0923-7534
Full text not available from this repository. (Request a copy)Abstract
Background: Severe up to life-threatening neuropathy has been observed in patients with hereditary neuropathies receiving vincristine. Case report: A 52-year-old female painter suffering from high-grade non-Hodgkin's lymphoma (stage IVB) was treated with a total of 4 mg of vincristine during two courses of CHOP chemotherapy (cyclophosphamide, vincristine, adriamycin, prednisone). At onset of treatment no neurological problems were reported. There was good lymphoma response to chemotherapy. At the same time, however, the patient gradually developed dysphagia, dysarthria, muscular weakness of both lower and upper extremities, areflexia, paraesthesia of the fingertips and bilateral sensory impairment of feet and lower legs. These symptoms continually worsened over a period of seven weeks until she was unable to walk or to perform her work. Electrophysiological studies showed peripheral axonal and demyelinative sensorimotor neuropathy in correlation to histological findings. Molecular analysis revealed 17p11.2 duplication typical for Charcot-Marie-Tooth disease IA. While continuing chemotherapy without the use of vincristine the patient's neurologic symptoms slowly recovered within six months. Conclusion: Prior to administration of vincristine family and patient history as well as physical examination should be performed carefully to look for underlying hereditary neuropathy. For those patients with a clinical history or symptoms suggestive for CMT nerve conduction velocity studies and on an individual base even molecular genetic analysis are neccessary to prevent serious neurologic complications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEREDITARY MOTOR; SCHWANN-CELLS; GENE DOSAGE; PMP22 GENE; MYELIN; TYPE-1A; NEUROPATHIES; DUPLICATION; EXPRESSION; MUTATIONS; Charcot-Marie-Tooth disease; chemotherapy; hereditary motor and sensory neuropathy; PMP22; vincristine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2022 09:28 |
| Last Modified: | 26 Apr 2022 09:28 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42412 |
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