Heep, Markus and Odenbreit, Stefan and Beck, Daniela and Decker, Jochen and Prohaska, Elke and Rieger, Ulrich and Lehn, Norbert (2000) Mutations at four distinct regions of the rpoB gene can reduce the susceptibility of Helicobacter pylori to rifamycins. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 44 (6). pp. 1713-1715. ISSN 0066-4804
Full text not available from this repository. (Request a copy)Abstract
The transformation of a panel of rpoB mutations (codons 525 to 586) from rifampin-resistant donor strains into Helicobacter pylori 2802A confirmed the MICs associated with the respective mutations. RpoB V149X random mutations were generated and induced different levels of resistance, depending on the replacement amino acid. Mutagenesis of the rpoB gene at codon position 701 (R701H) induced low-level resistance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ESCHERICHIA-COLI; RIFAMPICIN RESISTANCE; RNA-POLYMERASE; BETA-SUBUNIT; MUTANTS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2022 09:31 |
| Last Modified: | 26 Apr 2022 09:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42413 |
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