Kammerl, Martin C. and Schaefer, R. M. and Schweda, Frank and Schreiber, M. and Riegger, Guenter A. J. and Kraemer, Bernhard K. (2000) Extracorporal therapy with AN69 membranes in combination with ACE inhibition causing severe anaphylactoid reactions: still a current problem? CLINICAL NEPHROLOGY, 53 (6). pp. 486-488. ISSN 0301-0430
Full text not available from this repository. (Request a copy)Abstract
The negatively charged membrane AN69 is known to evoke anaphylactoid reactions both without and with concomitant ACE inhibition. Underlying reasons are mainly the induction of bradykinin release due to the negatively charged membrane and the reduced degradation of bradykinin due to ACE inhibition. This complication has been reported repeatedly, but anaphylactoid reactions still occur in clinical practice. We recently had to treat two patients who suffered anaphylactoid reactions during extracorporal therapy with an AN69 membrane and simultaneous ACE inhibition. The first incident occurred in a patient on hemodialysis, the second was in a patient on continuous veno-venous hemofiltration. An anaphylactoid reaction induced by an AN69 membrane during continuous, extracorporal treatment in combination with ACE inhibition has not been reported so far. Our report intends to serve as a reminder that the potentially lethal combination of AN69 membranes with ACE inhibitor treatment should be avoided.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HEMODIALYSIS; BRADYKININ; DIALYSIS; anaphylactoid reaction; AN69; ACE inhibition; dialysis; hemofiltration |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2022 10:06 |
| Last Modified: | 26 Apr 2022 10:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42418 |
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