Michel, Jan and Schwarz, Herbert (2000) Expression of soluble CD137 correlates with activation-induced cell death of lymphocytes. CYTOKINE, 12 (6). pp. 742-746. ISSN 1043-4666
Full text not available from this repository.Abstract
CD137 is a member of the tumour necrosis factor receptor family which delivers a potent co-stimulatory signal to T lymphocytes, Soluble forms of CD137 (sCD137) can be found at enhanced levels in sera of patients with rheumatoid arthritis. Here we show that expression of sCD137 lags behind that of membrane-bound CD137 (mCD137) by about 24h, In fully activated lymphocytes, time of maximum increase and level of expression of sCD137 were at day 2 and 3, respectively, Expression of sCD137 in lymphocytes requires strong activation, and levels of sCD137 correlate negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. Since activation of lymphocytes through membrane-bound CD137 delivers a potent stimulatory signal, sCD137 may provide a negative control mechanism for immune responses. (C) 2000 Academic Press.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FACTOR-RECEPTOR FAMILY; HUMAN 4-1BB; GROWTH; MEMBER; ILA; PROLIFERATION; ILA/4-1BB; SURVIVAL; CD137; activation-induced cell death; apoptosis; lymphocyte |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2022 10:12 |
| Last Modified: | 26 Apr 2022 10:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42420 |
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