Halmos, Balazs and Szalay, Ferenc and Cserniczky, Tamas and Nemesanszky, Elemer and Lakatos, Peter and Barlage, Stefan and Schmitz, Gerd and Romics, Laszlo and Csaszar, Albert (2000) Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population. DIGESTIVE DISEASES AND SCIENCES, 45 (6). pp. 1091-1095. ISSN 0163-2116
Full text not available from this repository.Abstract
We sought to determine the distribution of vitamin D receptor genotypes defined by the BsmI polymorphism and to investigate their association with bone mineral density in patients with primary biliary cirrhosis. Vitamin D receptor genotype and bone mineral density at the lumbar spine was determined in 31 female Hungarian patients with primary biliary cirrhosis and 51 age-matched healthy female controls. The genotype frequency (BB: 45%, Bb: 32%, bb: 22%) of the patients was significantly different from the control group (P = 0.01) due to an overrepresentation of the BB genotype, There was an apparent trend, not reaching statistical significance, for a lower bone mineral density in both the patient and control groups carrying a B allele. In conclusion, we found a strikingly high frequency of the BB genotype in patients with primary biliary cirrhosis, which raises questions about hormonal influences on the development of primary biliary cirrhosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MINERAL DENSITY; GENE POLYMORPHISMS; PREMENOPAUSAL WOMEN; CALCIUM-ABSORPTION; ALLELIC VARIATION; OSTEOPOROSIS; SUSCEPTIBILITY; TURNOVER; DISEASE; LOCUS; vitamin D receptor; genotypes; bone mineral density; primary biliary cirrhosis; autoimmunity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2022 10:30 |
| Last Modified: | 26 Apr 2022 10:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42422 |
Actions (login required)
 |
View Item |
