Kumar, Sunil and Ziereis, Klaus and Wiegrebe, Wolfgang and Mueller, Klaus (2000) Medicinal plants from Nepal: evaluation as inhibitors of leukotriene biosynthesis. JOURNAL OF ETHNOPHARMACOLOGY, 70 (3). pp. 191-195. ISSN 0378-8741
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The methanolic extracts of 25 different Nepalese medicinal plants were tested for their activity to inhibit the biosynthesis of leukotriene B-4 in bovine polymorphonuclear leukocytes. The selected indigenous plants are used in traditional herb remedies to treat inflammatory diseases such as asthma, bronchitis, rheumatism, and skin disorders presumed to be mediated by leukotrienes. The leaves of Zanthoxylum nepalensis were shown to be the most potent inhibitor with an IC50 value of 11 mu g/ml. The extracts obtained from Astercantha longifolia and Hedychium ellipticum also exhibited potent inhibitory action with IC50 values of 20 and 22 mu g/ml, respectively. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 5-LIPOXYGENASE; ALKALOIDS; antiinflammatory activity; leukotrienes; 5-lipoxygenase; Nepalese plants; traditional medicine |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Apr 2022 14:31 |
| Last Modified: | 26 Apr 2022 14:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42443 |
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