Mueller-Ladner, Ulf and Gay, R. E. and Gay, S. (2000) Activation of synoviocytes. CURRENT OPINION IN RHEUMATOLOGY, 12 (3). pp. 186-194. ISSN 1040-8711
Full text not available from this repository.Abstract
The evaluation of molecular pathways has revealed various novel insights into rheumatoid arthritis pathophysiology during the past year. in addition, there is an increasing tendency toward analysis not merely of a single mechanism but rather of data addressing a substantial part of the cascade of events leading to cellular activation. Because synovial fibroblasts are key cells involved in joint destruction, this review outlines the events that trigger or inhibit the crucial pathways leading to their aggressive behavior. Major topics include cellular and humoral interactions (frequently modulated by cytokines), intracellular signaling and upregulation of gene transcription, and the deleterious effects on articular homeostasis. Curr Opin Rheumatol 2000. 12:186-194 (C) 2000 Lippincott Williams & Wilkins, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; RHEUMATOID-ARTHRITIS; SYNOVIAL FIBROBLASTS; CELLS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 29 Apr 2021 10:08 |
| Last Modified: | 29 Apr 2021 10:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42505 |
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