Schulz, Michaela B. and Daniels, Rolf (2000) Hydroxypropylmethylcellulose (HPMC) as emulsifier for submicron emulsions: influence of molecular weight and substitution type on the droplet size after high-pressure homogenization. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 49 (3). pp. 231-236. ISSN 0939-6411
Full text not available from this repository. (Request a copy)Abstract
Hydroxypropylmethylcellulose (HPMC) is a known emulsifier as well as a common viscosity enhancer in eye drops. Therefore, HPMC stabilized emulsions appear as interesting drug carriers for ophthalmic use and as a suitable treatment of dry eye syndrome. Since submicron emulsions are known to have an improved drug delivery, attempts were made to reduce the emulsion's droplet size by high-pressure homogenization. Droplet size was dependent on the homogenization pressure and the polymer content. Differences were found between emulsions stabilized with higher and lower molecular weight HPMC. Smaller droplet sizes were obtained with the shorter chained HPMC. No considerable influence of the substitution type was observed. (C) 2000 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYDROXYPROPYL METHYL CELLULOSE; ENHANCED TRANSDERMAL DELIVERY; CONTROLLED DRUG-DELIVERY; LIPID NANOPARTICLES SLN; SILICONE OIL-EMULSIONS; VEHICLE; METHYLCELLULOSE; PARAMETERS; STABILITY; DIAZEPAM; hydroxypropylmethylcellulose; cellulose ether; surface tension; molecular weight; viscosity; submicron emulsion; droplet size; laser diffractometry; ophthalmic application |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 May 2022 14:29 |
| Last Modified: | 03 May 2022 14:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42508 |
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