Koch, H. J. and Raschka, C. and Wiegand, R. (2000) Influence of heart failure on pharmacokinetics. HERZ KREISLAUF, 32 (5). pp. 172-177. ISSN 0046-7324
Full text not available from this repository.Abstract
Major symptoms of heart failure are venous congestion and reduced perfusion of organs These symptoms can indirectly alter absorption from the GIT-tract and transportation of drugs in blood vessels to peripheral compartments. Apart from hepatic metabolism renal elimination is influenced as renal blood flow is reduced during heart failure, The delayed absorption causes low drug levels whereas reduced elimination and altered distribution may be responsible for elevated drug levels, which warrant regular assessment of drug effect and drug monitoring in case of heart failure. The latter is particulary important for drugs with narrow therapeutic windows. Simulation of concentration vs. time curves can help to predict steady stale concentrations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHARMACODYNAMICS; ABSORPTION; FUROSEMIDE; CAPTOPRIL; AGENTS; heart failure; clinical pharmacokinetics; simulation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Apr 2021 10:35 |
| Last Modified: | 28 Apr 2021 10:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42514 |
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