Emery, Patrick and Stanewsky, Ralf and Helfrich-Foerster, Charlotte and Emery-Le, Myai and Hall, Jeffrey C. and Rosbash, Michael (2000) Drosophila CRY is a deep brain circadian photoreceptor. NEURON, 26 (2). pp. 493-504. ISSN 0896-6273
Full text not available from this repository. (Request a copy)Abstract
cry (cryptochrome) is an important clock gene, and recent data indicate that it encodes a critical circadian photoreceptor in Drosophila. A mutant allele, cry(b), inhibits circadian photoresponses. Restricting CRY expression to specific fly tissues shows that CRY expression is needed in a cell-autonomous fashion for oscillators present in different locations. CRY overexpression in brain pacemaker cells increases behavioral photosensitivity, and this restricted CRY expression also rescues all circadian defects of cryb behavior. As wild-type pacemaker neurons express CRY, the results indicate that they make a striking contribution to all aspects of behavioral circadian rhythms and are directly light responsive. These brain neurons therefore contain an identified deep brain photoreceptor, as well as the other circadian elements: a central pacemaker and a behavioral output system.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERIOD CLOCK GENE; NERVOUS-SYSTEM; BEHAVIORAL RHYTHMS; LIGHT-ENTRAINMENT; VISUAL-SYSTEM; DARK CYCLES; DOUBLE-TIME; PROTEIN; MELANOGASTER; MUTANTS; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Alumni or Retired > Organisation der inneren Uhr auf neuronaler Ebene (Prof. Dr. Charlotte Förster) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 May 2022 07:27 |
| Last Modified: | 16 May 2022 07:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42541 |
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