Bogner, Ludwig and Schiessl, I. and Spiegler, W. and Meyer, B. and Herbst, M. (2000) Quantification of radiation lung injuries. ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 172 (5). pp. 472-476. ISSN 1438-9029
Full text not available from this repository. (Request a copy)Abstract
Purpose: The aim of this paper is to find techniques for quantifying radiation lung injury after irradiation with lung involvement to improve an early diagnosis. Methods: The case of a patient with NSCLC was used to demonstrate different methods in order to quantify a developing pneumopathy after radiation treatment. By means of HRCT studies in the follow-up, a procedure was developed by defining a test-ROI in high-dose areas of the lung and evaluating the corresponding HU-histogramm for the parameters of the lung peak. Changes during the follow-up can be derived from the differential HU-histogram by the determination of a parameter called Delta HU(rel), which quantifies the shift to higher HU values. Alternatively, a Fourier analysis of the lung pattern within the test-ROI results in a Fourier amplitude distribution, which reacts sensitively to changes during the followup. Furthermore, a Fourier-frequency histogram can be derived which is independent of the spatial orientation of the density pattern. Results: From the HRCT follow-up study, values for Delta HU(rel) can be derived to be 0.24, 0.44, and 0.50 (56, 100 and 422 days after beginning the treatment). The differential Fourier frequency-histogram presentations demonstrate pronounced pattern changes. Conclusion: The presented methods demonstrate possibilities to quantify radiation lung injury. The proven sensitivity can possibly be improved after the introduction of a breath triggered HRCT technique.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | QUANTITATIVE CT; radiation lung injury; pneumopathy; HRCT; lung |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2022 06:30 |
| Last Modified: | 17 May 2022 06:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42555 |
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