Heep, Markus and Rieger, Ulrich and Beck, Daniela and Lehn, Norbert (2000) Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 44 (4). pp. 1075-1077. ISSN 0066-4804
Full text not available from this repository. (Request a copy)Abstract
A clinical isolate of Helicobacter pylori that developed resistance to rifabutin during therapy carried an rpoB gene that retained a wild-type cluster region sequence but had acquired a novel codon 149 (V149F) mutation. In transformation experiments, the mutation was shown to confer high-level rifabutin resistance. The equivalent mutation (V176F) was present in several resistant isolates of Mycobacterium tuberculosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POLYMERASE BETA-SUBUNIT; NEW-YORK-CITY; ESCHERICHIA-COLI; RNA-POLYMERASE; RIFAMPICIN-RESISTANCE; STRAINS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2022 06:13 |
| Last Modified: | 17 May 2022 06:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42599 |
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