Wang, Xu-dong and Meier, Robert J. and Schmittlein, Carina and Schreml, Stephan and Schaeferling, Michael and Wolfbeis, Otto S. (2015) A water-sprayable, thermogelating and biocompatible polymer host for use in fluorescent chemical sensing and imaging of oxygen, pH values and temperature. SENSORS AND ACTUATORS B-CHEMICAL, 221. pp. 37-44. ISSN 0925-4005,
Full text not available from this repository. (Request a copy)Abstract
We report on the use of a sprayable and thermogelating biomaterial (Poloxamer (TM); a.k.a. Pluronic (TM)) in optical imaging of pH values, local oxygen and temperature. The material is highly biocompatible and easy to handle. We also show that the material is well permeable to oxygen (thus making it a good choice for use in oxygen sensors), and is stable in liquid solution and at elevated temperature. We demonstrate its applicability in optical sensors for oxygen, pH and temperature. This was accomplished by incorporating appropriate luminescent probes in various kinds of microparticles (which act as hosts for the probes and prevent dye leaching and aggregation), and then dispersing the microparticles in the thermogelating polymer. The resulting sensor gels were deposited on the surface of interest via spraying at temperatures of <20 degrees C At these temperatures, the gels adhere well to the target, even on uneven surfaces such as skin, wounds, and bacterial cultures. If temperature is risen to above 25 degrees C, the gels form a thin and soft but solid sensing layer which, however, can be simply removed from surface of interest by cooling and wiping it off, or by washing with water. Sprayable thermogelating sensors present obvious advantages over other sensors by not causing damage to the surface of interest. In our perception, the sensing materials also have wide further applicability in sensors for other species including clinically relevant gases, enzyme substrates (such as glucose or lactate) and ions. (C) 2015 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VIVO; PHOTODYNAMIC THERAPY; SENSITIVE PAINT; SENSOR FILMS; NANOPARTICLES; GELATION; SCREEN; Chemical sensing; Imaging; Biocompatible polymer; Sprayable sensor; Fluorescence; Poloxamer; Pluronic; Oxygen sensor; pH sensor; Temperature sensor |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Apr 2019 06:18 |
| Last Modified: | 29 Apr 2019 06:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/4266 |
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