Gleich, Otto and Dooling, R. J. and Ryals, B. M. (2000) Neither endocochlear potential nor Tegmentum vasculosum are affected in hearing impaired Belgian Waterslager canaries. HEARING RESEARCH, 142 (1-2). pp. 56-62. ISSN 0378-5955
Full text not available from this repository. (Request a copy)Abstract
We previously showed that the Belgian Waterslager canary strain is affected by a hereditary hearing loss that is associated with a reduced number of hair cells and hair cell pathologies in the basilar papilla. Since hair cell pathologies were also present in the sacculus, Weisleder et al. (1994) suggested that these birds are afflicted by Scheibe's like dysplasia, a cochleo-saccular defect, in mammals, cochleo-saccular defects are characterized primarily by the lack of an endocochlear potential and abnormalities in the Stria vascularis which only secondarily lead to hair cell loss (Steel and Beck, 1983; Steel, 1994; 1995). Here we report the endocochlear potential of six ears from three non-Belgian Waterslager canaries and three ears of two Belgian Waterslager canaries to decide if Waterslager canaries are affected by a cochleo-saccular or by a neuroepithelial defect. The mean endocochlear potential was 17.6 +/- 2.5 mV in the non-Waterslager canaries and 20.3 +/- 0.6 mV in Waterslager canaries. In addition, and consistent with the presence of a normal endocochlear potential, light microscopy of the tegmentum vasculosum provided no evidence for pathology. These data show that Belgian Waterslager canaries are affected by a neuroepithelial rather than a cochleo-saccular inner ear defect. (C) 2000 Elsevier Science B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INNER-EAR ABNORMALITIES; SERINUS-CANARIUS; BASILAR PAPILLA; POTASSIUM CONCENTRATION; COCHLEAR POTENTIALS; AUDITORY-THRESHOLDS; ADULT CHICKENS; SINGLE-FIBER; FUROSEMIDE; CELLS; inner ear; bird; cochlear pathology; hereditary hearing loss; endocochlear potential |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2022 13:42 |
| Last Modified: | 17 May 2022 13:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42679 |
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