Mueller-Ladner, Ulf and Judex, Martin and Ballhorn, Wibke and Kullmann, Frank and Distler, Oliver and Schlottmann, Klaus and Gay, Renate E. and Schoelmerich, Juergen and Gay, Steffen (2000) Activation of the IL-4 STAT pathway in rheumatoid synovium. JOURNAL OF IMMUNOLOGY, 164 (7). pp. 3894-3901. ISSN 0022-1767
Full text not available from this repository. (Request a copy)Abstract
STATs act as second messenger after binding of a signaling molecule to its receptor. IL-4 STAT is directly involved in the Il-4-dependent gene transcription in the nucleus. We examined the expression and activation of IL-4 STAT and its related kinase Jak-1 in rheumatoid synovium, Rheumatoid arthritis (RA) synovial frozen sections of patients with short-term (<1 year) and long-term disease (>2 years) were examined using in situ hybridization and immunohistochemistry. IL-4 STAT mRNA could be detected in synovium of patients with short-term and long-term RA, The most intensive expression of IL-4 STAT mRNA could be seen in follicular inflammatory infiltrates, In the synovial lining, both fibroblasts and macrophages expressed IL-4 STAT mRNA. IL-4 STAT and Jak-1 protein was expressed by synoviocytes, and up-regulation could be induced after stimulation with IL-4. Activation of IL-4 STAT was reflected by phosphorylation of IL-4 STAT. The results indicate that IL-4 STAT is involved in key pathomechanisms in RA synovium and that IL-4 STAT-dependent pathways operate in early and late stages of the disease and presumably contribute to inhibitory immune mechanisms in RA synovium.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTERLEUKIN-1 RECEPTOR ANTAGONIST; NECROSIS-FACTOR-ALPHA; COLLAGEN-INDUCED ARTHRITIS; NORMAL HUMAN CARTILAGE; IN-SITU HYBRIDIZATION; TRANSCRIPTION FACTOR; TYROSINE PHOSPHORYLATION; SIGNAL-TRANSDUCTION; CYTOKINE PRODUCTION; GENE-EXPRESSION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2022 13:27 |
| Last Modified: | 17 May 2022 13:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42687 |
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