Brand, K. and Donath, B. and Fischer, C. and Neumeier, D. and Rogler, Gerhard (2000) NF-kappa B-regulated gene expression inflammatory bowel disease. MEDIZINISCHE WELT, 51 (4). pp. 31-35. ISSN 0025-8512
Full text not available from this repository.Abstract
Target gene products of the NF-kappa cB/Rel transcription factor family such as cytokines, chemokines and adhesion molecules play on important role in the regulation of the intestinal immune system. Dysregulation of the NF-kappa B/Rel system and the increase of related genes in cells of the intestinal mucosa, is involved in the pathogenesis of inflammatory bowel disease (IBD). A number of drugs used in the treatment of IBD has been shown to inhibit NF-kappa B activation. A more specific modulation of this system could lead to more effective therapy with fewer side effects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | KINASE COMPLEX; SIGNAL-TRANSDUCTION; GLUCOCORTICOID RECEPTOR; EPITHELIAL-CELLS; CROHNS-DISEASE; P65 SUBUNIT; ACTIVATION; INHIBITION; COLITIS; ALPHA; NF-kappa B; inflammatory bowel disease; pharmacological therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 May 2022 13:33 |
| Last Modified: | 17 May 2022 13:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42693 |
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