Wahba, Alexander and Rothe, Gregor and Lodes, Heiko and Barlage, Stefan and Schmitz, Gerd and Birnbaum, Dietrich E. (2000) Effects of extracorporeal circulation and heparin on the phenotype of platelet surface antigens following heart surgery. THROMBOSIS RESEARCH, 97 (6). pp. 379-386. ISSN 0049-3848
Full text not available from this repository. (Request a copy)Abstract
In this prospective study, the time-dependent effects of extracorporeal circulation and heparin-mediated effects on platelet surface antigens in vitro were investigated using whole blood flow cytometry. Blood samples were drawn prior to and following extracorporeal circulation in 89 patients. The response of surface antigen expression (glycoprotein IIb/IIIa, P-selectin, and glycoprotein Ib) with and without in vitro stimulation was measured. A significant correlation of the duration of extracorporeal circulation with the postoperative response of glycoprotein IIb/IIIa, glycoprotein Ib, and P-selectin to in vitro activation was found. Postoperative P-selectin and glycoprotein Ib expression stimulated with ADP correlated to blood loss; Heparin in vitro significantly reduced glycoprotein Ib expression. Heparin, as well as the duration of extracorporeal circulation, independently correlated to phenotypic changes of platelets following extracorporeal circulation. The significant correlation of these variables to postoperative blood loss demonstrates their relevance to platelet function in vivo. (C) 2000 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARDIOPULMONARY BYPASS; ACTIVATED PLATELETS; AGGREGATION; DYSFUNCTION; RECEPTORS; COMPLEX; heart surgery; extracorporeal circulation; platelet function; flow cytometry; heparin effects |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 May 2022 10:09 |
| Last Modified: | 24 May 2022 10:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42757 |
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