Konecna, Leona and Yan, Ming S. and Miller, Luitpold E. and Schoelmerich, Juergen and Falk, Werner and Straub, Rainer H. (2000) Modulation of IL-6 production during the menstrual cycle in vivo and in vitro. BRAIN BEHAVIOR AND IMMUNITY, 14 (1). pp. 49-61. ISSN 0889-1591
Full text not available from this repository.Abstract
During the menstrual cycle (MC), premenopausal women experience changes in basal temperature and their physical condition and well-being. Premenopausal female patients with chronic inflammatory diseases demonstrate changes in disease activity during the MC. The study was initiated to explore reasons for these phenomena. The sex hormone-modulated lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) secretion in a whole blood assay, serum IL-6 concentration, and serum sex hormone concentrations were studied throughout the MC in five healthy female subjects (median, 28 years; mean, 31.2 +/- 2.2 pears, 26-38 years). Serum IL-6 concentration demonstrated a significant increase in the luteal phase of the MC and was elevated when serum dehydroepiandrosterone (DHEA) was low and vice verse. DHEA decreased LPS-induced IL-6 secretion at six of seven time points during the MC (DHEA, p = .047). In contrast, beta-estradiol and testosterone increased LPS-induced IL-6 secretion in six of seven time points during the MC (significant for testosterone, p = .005). The study demonstrates oscillation of serum IL-6 concentration during the MC and the marked MC-dependent modulation of IL-6 secretion by sex hormones. These mechanisms may be involved in the changes in the basal temperature, the general condition, and, in patients with chronic inflammatory diseases, of disease activity during the MC. (C) 2000 Academic Press.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INHIBITS INTERLEUKIN-6 PRODUCTION; HUMAN ARTICULAR CHONDROCYTES; NECROSIS-FACTOR-ALPHA; RHEUMATOID-ARTHRITIS; MONONUCLEAR-CELLS; HUMAN ENDOMETRIUM; GENE-EXPRESSION; IN-VITRO; RECEPTOR; PHASE; menstrual cycle; IL-6; TNF; dehydroepiandrosterone; testosterone; beta-estradiol |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 May 2022 12:56 |
| Last Modified: | 24 May 2022 12:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42770 |
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