Hans, W. and Schoelmerich, Juergen and Gross, V. and Falk, Werner (2000) Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice. EUROPEAN CYTOKINE NETWORK, 11 (1). pp. 67-74. ISSN 1148-5493
Full text not available from this repository. (Request a copy)Abstract
There is increasing evidence that IL-12 and Th1-cytokines play an important role in intestinal inflammation. We therefore examined the role of IL-12 and interferon-gamma (IFN-1) in our model of dextran sulfate-induced acute colitis in mice. Treatment of mice with rmIL-12 during colitis induction resulted in severe aggravation as demonstrated by a greater loss of body weight, an increase of the histological parameters, and reduction of myeloperoxidase activity in colonic biopsies. Depletion of neutrophils in mice also led to aggravation of colitis. Neutralization of IFN-gamma in IL-12-treated mice with colitis inhibited these effects of IL-12. Neutralization of endogenous IFN-1, or IL-12 with specific antibodies in DSS-treated mice, however, had only weak ameliorating effects. Since IL-12 and IFN-1, have been shown to mediate experimental chronic colitis we conclude that the transition from a macrophage/neutrophil determined response to a Th-cell response promotes chronic intestinal inflammation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CD4(+) T-CELLS; COMBINED IMMUNODEFICIENT MICE; NECROSIS-FACTOR-ALPHA; C.B-17 SCID MICE; BOWEL-DISEASE; ULCERATIVE-COLITIS; CYTOKINE PRODUCTION; STIMULATORY FACTOR; INTESTINAL-MUCOSA; MONONUCLEAR-CELLS; inflammatory bowel disease; intestinal inflammation; neutralization; IL-12 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 May 2022 13:31 |
| Last Modified: | 24 May 2022 13:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42776 |
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