Mahboobi, Siavosh and Dechant, Irene and Reindl, Hans and Pongratz, Herwig and Popp, Alfred and Schollmeyer, Dieter (2000) Synthesis of bis(indolylmaleimide) macrocycles. JOURNAL OF HETEROCYCLIC CHEMISTRY, 37 (2). pp. 307-329. ISSN 0022-152X
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The synthesis of a novel class of macrocyclic bis(indolylmaleimides) is reported. The key step involves the intermolecular connection of 2,2'-bridged indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione (dibromomaleimide) derivatives. The bis(indolylmaieimides) afforded by this method were further processed by intramolecular nucleophilic substitution of the remaining bromo substituents forming flexible N-substituted macrocycles (9a-9j, 10a-10e) and, by connecting both maleimides, semi rigid macrocycles (7a-7xx).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REBECCAMYCIN; KINASE; INHIBITORS; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 May 2022 14:04 |
| Last Modified: | 31 May 2022 14:04 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42793 |
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