Zabel, Manfred and Breu, Josef and Rau, Franz and Range, Klaus-Jürgen and Krey, Volker and Uffrecht, Anka and Buschauer, Armin (2000) Absolute configuration of (-)-4-(3,4-dichlorophenyl)-4-(2-pyridyl)butanoic acid: essential information to determine crucial steric features of arpromidine-type histamine H-2 receptor agonists. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 56 (2). pp. 250-251. ISSN 0108-2701
Full text not available from this repository.Abstract
The structural information gained from the study of the chiral building block (R)-(-)-4-(3,4-dichlorophenyl)-4-(2-pyridyl)-butanoic acid-L-(-)-ephedrine [methyl(1-hydroxy-1-phenyl-prop-2-yl)ammonium 4-(3,4-dichlorophenyl)-4-(2-pyridyl)-butanoate], C10H16NO+. C15H12Cl2NO2-, can be used to deduce the absolute configuration of highly potent arpromidine-type histamine H-2 receptor agonists, as the chiral butanoic acid can be converted to (R)-(-)-3-(3,4-dichlorophenyl)-3-(2-pyridyl)propylamine and to the corresponding R-configured arpromidine analogue.
| Item Type: | Article |
|---|---|
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) Chemistry and Pharmacy > Institut für Anorganische Chemie > Alumni or Retired Professors > Prof. Dr. Klaus-Jürgen Range |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Jun 2022 06:12 |
| Last Modified: | 01 Jun 2022 06:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42832 |
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