Gasche, Christoph and Schoelmerich, Juergen and Brynskov, Jorn and D'Haens, Geert and Hanauer, Stephen B. and Irvine, Jan E. and Jewell, Derek P. and Rachmilewitz, Daniel and Sachar, David B. and Sandborn, William J. and Sutherland, Lloyd R. (2000) A simple classification of Crohn's disease: Report of the Working Party for the world congresses of gastroenterology, Vienna 1998. INFLAMMATORY BOWEL DISEASES, 6 (1). pp. 8-15. ISSN 1078-0998, 1536-4844
Full text not available from this repository.Abstract
Crohn's disease is a heterogeneous entity. Previous attempts of classification have been based primarily on anatomic location and behavior of disease. However, no uniform definition of patient subgroups has yet achieved broad acceptance. The aim of this international Working Party was to develop a simple classification of Crohn's disease based on objective variables. Eight outcome-related variables relevant to Crohn's disease were identified and stepwise evaluated in 413 consecutive cases, a database survey, and by clinical considerations. Allocation of variables was conducted with well-defined Crohn's disease populations from Europe and North America. Cross-table analyses were performed by chi-square testing. Three variables were finally elected: Age at Diagnosis [below 40 years (A1), equal to or above 40 years (A2)], Location [terminal ileum (L1), colon (L2), ileocolon (L3), upper gastrointestinal (L4)], and Behavior [nonstricturing nonpenetrating (B1), stricturing (B1), penetrating (B3)]. The allocation of patients to these 24 subgroups proved feasible and resulted in specific disease cluster s. Cross-table analyses revealed associations between Age at Diagnosis and Location, and between Behavior and Location (all p < 0.001). The Vienna classification of Crohn's disease provides distinct definitions to categorize Crohn's patients into 24 subgroups. Operational guidelines should be used for the characterization of patients in clinical trials as well as for correlation of particular phenotypes with putative biologic markers or environmental factors.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY BOWEL-DISEASE; POSTOPERATIVE RECURRENCE; PREVALENCE; ANTIBODIES; COUNTY; FORMS; Crohn's disease; classification; age; location; behavior; stratification; clinical research |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Jun 2022 09:16 |
| Last Modified: | 07 Jun 2022 09:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42854 |
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