Mueller-Ladner, Ulf and Nishioka, K. (2000) p53 in rheumatoid arthritis: friend or foe? ARTHRITIS RESEARCH, 2 (3). pp. 175-178. ISSN 1465-9913
Full text not available from this repository.Abstract
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, amd apoptotic cell death in rheumatoid arthritis (RA) synovium. In addition, the development of normal synovial fibroblasts into transformed-appearing aggressive synovial fibroblasts may be triggered by the lack of antiproliferative factors, such as p53, p53-associated molecules, other tumor suppressors, as well as by upregulation of anti-apoptotic genes. Therefore, data derived from experiments such as those performed by Tak and colleagues in this issue of Arthritis Research not only enrich the intensive discussion addressing the impact of p53 on RA pathophysiology, they also may facilitate development of novel therapeutic approaches including p53-targeted gene therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-SUPPRESSOR GENE; FIBROBLAST-LIKE SYNOVIOCYTES; SYNOVIAL FIBROBLASTS; DNA-DAMAGE; MUTATIONS; APOPTOSIS; EXPRESSION; CANCER; OVEREXPRESSION; INHIBITION; gene therapy; MDM2; p53; p73; rheumatoid arthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Apr 2021 06:40 |
| Last Modified: | 28 Apr 2021 06:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42922 |
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