Pap, T. and Mueller-Ladner, Ulf and Gay, R. E. and Gay, S. (2000) Fibroblast biology - Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. ARTHRITIS RESEARCH, 2 (5). pp. 361-367. ISSN 1465-9913
Full text not available from this repository.Abstract
There is growing evidence that activated synovial fibroblasts, as part of a complex cellular network, play an important role in the pathogenesis of rheumatoid arthritis. In recent years, significant progress has been made in elucidating the specific features of these fibroblasts. It has been understood that although macrophage and lymphocyte secreted factors contribute to their activation, rheumatoid arthritis synovial fibroblasts (RA-SFs) do not merely respond to stimulation by pro-inflammatory cytokines, but show a complex pattern of molecular changes also maintained in the absence of external stimulation. This pattern of activation is characterized by alterations in the expression of regulatory genes and signaling cascades, as well as changes in pathways leading to apoptosis. These together result in the upregulation of adhesion molecules that mediate the attachment of RA-SFs to the extracellular matrix and in the overexpression of matrix degrading enzymes that mediate the progressive destruction of the joints. In addition, activated RA-SFs exert specific effects on other cell types such as macrophages and lymphocytes. While the initiating step in the activation of RA-SFs remains elusive, several key pathways of RA-SF activation have been identified. However, there is so far no single, specific marker for this phenotype of RA-SF. It appears that activated RA-SFs are characterized by a set of specific properties which together lead to their aggressive behavior.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; TUMOR-SUPPRESSOR GENE; MESSENGER-RNA; CATHEPSIN-L; C-FOS; MATRIX METALLOPROTEINASE-1; ARTICULAR-CARTILAGE; TISSUE INHIBITOR; RESPONSE GENES; fibroblasts; rheumatoid arthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 28 Apr 2021 06:02 |
| Last Modified: | 28 Apr 2021 06:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/42923 |
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